This paper describes a unique deepwater brachiopod fauna from the upper part of the Talung Formation at the Dongpan Section, southern Guangxi, South China. This brachiopod fauna includes 10 species belonging to 10 genera. New taxa are Anidanthus mucronata n. sp., Dongpanoproductus elegans n. gen. and sp., Costatumulus dongpanensis n. sp., and Spinomarginifera semicircridge n. sp. This fauna is characterized by small, thin-shelled species with high abundance and low diversity, and therefore is different in generic and species composition from the coeval faunas of the Late Permian limestone facies in South China. The brachiopod fauna can be safely assigned to the latest Changhsingian as indicated by the presence of abundant Paracrurithyris pigmaea, the immediately underlying radiolarian Neoalbaillella optima Zone of late Changhsingian age, and the overlying ammonoid Ophiceras sp. cf. O. tingi Tien of the lowest Triassic. This fauna is most likely to have lived in a deepwater environment as indicated by coexistence with the radiolarian Latentifistularia, small thin-shelled brachiopods, and the dominance of silica-bearing mudstone.